Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412864 | 0.90 | SSTR5 (0.34) | SSTR5RETGSK3BDYRK1AWNT1 | |
| SCHEMBL4418731 | 0.88 | GSK3B (0.32) | SSTR5RETGSK3BDYRK1AWNT1 | |
| SCHEMBL4423456 | 0.87 | S1PR1 (0.34) | SSTR5GSK3BDYRK1AWNT1 | |
| SCHEMBL4416789 | 0.87 | ACACB (0.38) | SSTR5GSK3BDYRK1AWNT1 | |
| SCHEMBL4427891 | 0.85 | SSTR5 (0.37) | SSTR5CYP2D6OPRD1KCNH2 | |
| SCHEMBL4412902 | 0.84 | ACACB (0.41) | SSTR5GSK3BDYRK1AWNT1 | |
| SCHEMBL4424719 | 0.84 | CYP2D6 (0.32) | SSTR5RETGSK3BDYRK1AWNT1 | |
| SCHEMBL4423563 | 0.83 | TTK (0.33) | RETGSK3BDYRK1AWNT1 | |
| SCHEMBL4427980 | 0.83 | GSK3B (0.33) | SSTR5GSK3BDYRK1AWNT1 | |
| SCHEMBL4423082 | 0.81 | IRAK4 (0.33) | GSK3BDYRK1AWNT1OPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571876-A1 | SUBSTITUTED SEVEN-MEMBERED HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | Merck Sharp & Dohme Corp. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146358-A1 | SUBSTITUTED SEVEN-MEMBERED HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |