Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 4/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.31 |
| ▸ | WNT1 | P04628 | 3/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | ADH5 | P11766 | 3/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423456 | 0.86 | S1PR1 (0.34) | TTKMAPK8GSK3BDYRK1AWNT1 | |
| SCHEMBL4424719 | 0.86 | CYP2D6 (0.32) | GSK3BDYRK1AWNT1RET | |
| SCHEMBL4416789 | 0.86 | ACACB (0.38) | GSK3BDYRK1AWNT1ADH5 | |
| SCHEMBL4427891 | 0.86 | SSTR5 (0.37) | ADH5 | |
| SCHEMBL4427980 | 0.85 | GSK3B (0.33) | GSK3BDYRK1AWNT1 | |
| SCHEMBL4418731 | 0.84 | GSK3B (0.32) | GSK3BDYRK1AWNT1RET | |
| SCHEMBL4412902 | 0.83 | ACACB (0.41) | TTKGSK3BDYRK1AWNT1ADH5 | |
| SCHEMBL2599528 | 0.83 | SSTR5 (0.39) | GSK3BDYRK1AWNT1RET | |
| SCHEMBL4423082 | 0.83 | IRAK4 (0.33) | TTKMAPK8GSK3BDYRK1AWNT1 | |
| SCHEMBL4430464 | 0.83 | HSP90AA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | claimed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |