Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599617 | 0.81 | PIK3CD (0.43) | CYP17A1CYP1A2ALDH1A1HTR6PIK3CD | |
| SCHEMBL2599665 | 0.77 | PIK3CD (0.38) | CYP17A1CYP1A2ALDH1A1HTR6PIK3CD | |
| SCHEMBL2599637 | 0.74 | APP (0.41) | CYP17A1CYP1A2HTR6PIK3CDPIK3CB | |
| SCHEMBL2599667 | 0.72 | AVPR1A (0.35) | CYP17A1CYP1A2HTR6FAAHPIK3CD | |
| SCHEMBL16332713 | 0.72 | CYP17A1 (0.34) | CYP17A1CYP1A2HTR6PIK3CDPIK3CB | |
| SCHEMBL16388793 | 0.71 | PIK3CA (0.37) | CYP17A1CYP1A2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL28927093 | 0.69 | CYP11B2 (0.62) | ALKBH1ALDH1A1KDM4E | |
| SCHEMBL15952657 | 0.67 | KIT (0.54) | ALKBH1ALDH1A1 | |
| SCHEMBL15953346 | 0.66 | KIT (0.53) | ALKBH1ALDH1A1 | |
| SCHEMBL26077214 | 0.66 | KIT (0.53) | ALKBH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |