Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HA1 | P13674 | 3/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12911323 | 0.79 | DYRK3 (0.43) | FLT3CDK5MEN1NPC1RAB9A | |
| SCHEMBL2130483 | 0.79 | CDK5 (0.55) | P4HA1P4HTMFLT3LDHADYRK2 | |
| SCHEMBL4065919 | 0.78 | MAPT (0.51) | FLT3CDK5MEN1KMT2ACDK1 | |
| SCHEMBL4065913 | 0.78 | MAPT (0.51) | FLT3CDK5MEN1KMT2ACDK1 | |
| SCHEMBL3205187 | 0.70 | FLT3 (0.43) | FLT3DYRK2CDK5FGFR1FLT1 | |
| SCHEMBL3193236 | 0.67 | GSK3B (0.55) | FLT3CDK5FGFR1FLT1KDR | |
| SCHEMBL68560 | 0.66 | P4HTM (1.00) | P4HA1P4HTMLDHAHCAR3NPC1 | |
| SCHEMBL29397057 | 0.66 | P4HTM (1.00) | P4HA1P4HTMLDHAHCAR3NPC1 | |
| SCHEMBL29683317 | 0.66 | P4HTM (1.00) | P4HA1P4HTMLDHAHCAR3NPC1 | |
| Potassium SCHEMBL30900922 | 0.64 | P4HTM (0.95) | P4HA1P4HTMLDHAHCAR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101132-A1 | New Substituted Oxindole Derivative | CLAESSON MARTINA (SE) | 2012-04-26 | — | — | US | disclosed |
| US-20090291982-A1 | New Substituted Oxindole Derivative 352 | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291982-A1 | New Substituted Oxindole Derivative 352 | PYGL, GSK3A, GSK3B | P4HA1 1114/4885P4HTM 2845/4885FLT3 3231/4885 |
| US-20120101132-A1 | New Substituted Oxindole Derivative | PYGL, GSK3A, GSK3B | P4HA1 979/4885P4HTM 2506/4885FLT3 3299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.