Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065913 | 1.00 | MAPT (0.51) | MAPTCDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL4060329 | 0.84 | CCNE1 (0.46) | MAPTCDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL4061274 | 0.82 | KDM4E (0.49) | MAPTCDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL4029976 | 0.82 | HRH4 (0.52) | CDK5CDK5R1GSK3AGSK3BCCNE1 | |
| SCHEMBL4064005 | 0.80 | HDAC4 (0.46) | MAPTCDK5CDK5R1GSK3AGSK3B | |
| Fumaric Acid SCHEMBL4059029 | 0.79 | HRH4 (0.47) | CDK5CDK5R1GSK3AGSK3BCCNE1 | |
| Fumaric Acid SCHEMBL4059019 | 0.79 | HRH4 (0.47) | CDK5CDK5R1GSK3AGSK3BCCNE1 | |
| Fumaric Acid SCHEMBL4059032 | 0.79 | HRH4 (0.47) | CDK5CDK5R1GSK3AGSK3BCCNE1 | |
| Hydrochloric Acid SCHEMBL4062061 | 0.79 | HDAC4 (0.45) | MAPTCDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL4065223 | 0.78 | L3MBTL3 (0.49) | CDK5CDK5R1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |