Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26004428 | 0.91 | SIGMAR1 (0.48) | SIGMAR1OPRK1OPRM1OPRD1CHRM2 | |
| SCHEMBL26004590 | 0.83 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1EBPSLC18A3 | |
| SCHEMBL26014211 | 0.83 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL26014956 | 0.83 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1EBPSLC18A3 | |
| SCHEMBL26004738 | 0.82 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL26015093 | 0.82 | SIGMAR1 (0.48) | SIGMAR1OPRD1CHRM2CHRM3 | |
| SCHEMBL26004354 | 0.82 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL25361889 | 0.81 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1OPRD1EBP | |
| SCHEMBL26014001 | 0.81 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1OPRD1EBP | |
| SCHEMBL26004429 | 0.81 | SIGMAR1 (0.46) | SIGMAR1OPRK1OPRM1OPRD1EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |