Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.39 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26005718 | 0.81 | HTR2C (0.49) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL31159703 | 0.79 | HTR2C (0.46) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL8548879 | 0.74 | ADRB1 (0.50) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL12081257 | 0.74 | HTR2C (0.47) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL22009927 | 0.72 | HTR6 (0.40) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL29556433 | 0.72 | HTR6 (0.40) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL23980840 | 0.72 | SLC18A3 (0.45) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL22009777 | 0.71 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL22697071 | 0.71 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL22009845 | 0.71 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023152698-A1 | 2-((4-((S)-2-(4-CHLORO-2-FLUOROPHENYL)-2-METHYLBENZO[D][1,3]DIOXOL-4-YL)PIPERIDIN-1-YL)METHYL)-1-(((S)-OXETAN-2-YL)METHYL)-1H-IMIDAZOLE DERIVATIVES AS ACTIVATORS OF THE GLP1 RECEPTOR FOR THE TREATMENT OF OBESITY | NOVARTIS AG (CH) | 2023-08-17 | — | — | WO | disclosed |