Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | SGK1 | O00141 | 5/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600540 | 0.91 | JAK3 (0.39) | LRRK2GSK3BABL1AXLROCK2 | |
| SCHEMBL2115072 | 0.88 | ABL1 (0.50) | LRRK2ABL1CAMKK2DYRK1AJAK3 | |
| SCHEMBL2600551 | 0.86 | MAP3K11 (0.43) | LRRK2ABL1SGK1ROCK2CDK2 | |
| SCHEMBL2600670 | 0.86 | MAP4K1 (0.42) | LRRK2GSK3BABL1SGK1AXL | |
| SCHEMBL2600566 | 0.83 | CHEK1 (0.34) | ABL1ROCK2ROCK1CDC42BPBCHEK1 | |
| SCHEMBL2600575 | 0.83 | MET (0.33) | DYRK1A | |
| SCHEMBL11968623 | 0.81 | SGK1 (0.56) | GSK3BABL1SGK1AXLCAMKK2 | |
| SCHEMBL2600653 | 0.79 | MAP4K1 (0.43) | GSK3BABL1ROCK2CLK4ROCK1 | |
| SCHEMBL2600632 | 0.78 | MAP4K1 (0.40) | LRRK2GSK3BABL1AXLCLK4 | |
| SCHEMBL11968645 | 0.77 | SGK1 (0.49) | ABL1SGK1AXLCAMKK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158647-B2 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | PDXK, MAP3K4, PDPK1 | LRRK2 1040/4885GSK3B 1137/4885ABL1 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.