SCHEMBL26007997

SCHEMBL26007997

Cc1cccc(C(C)(O)CC(=O)Nc2nc3c(F)cc(C#N)cc3n2C(C)(C)C)c1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
AR P10275 5/20 0.33
ACSS2 Q9NR19 1/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 1/20 0.32
CEPT1 Q9Y6K0 1/20 0.32
KLKB1 P03952 1/20 0.32
NPSR1 Q6W5P4 1/20 0.31
LDHA P00338 1/20 0.31
CETP P11597 1/20 0.31
RORC P51449 1/20 0.31
PDK1 Q15118 1/20 0.31
PDK2 Q15119 1/20 0.31
PDK3 Q15120 1/20 0.31
PDK4 Q16654 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21354694 0.92 AR (0.34) MEN1HPGDKMT2AARACSS2
SCHEMBL30315588 0.92 AR (0.34) MEN1HPGDKMT2AARACSS2
SCHEMBL18791698 0.91 ACSS2 (0.36) HPGDARACSS2PKMCEPT1
SCHEMBL18791697 0.91 ACSS2 (0.36) HPGDARACSS2PKMCEPT1
SCHEMBL20110989 0.91 ACSS2 (0.36) HPGDARACSS2PKMCEPT1
SCHEMBL21354593 0.86 AR (0.34) HPGDARACSS2RORC
SCHEMBL30315429 0.86 AR (0.34) HPGDARACSS2RORC
SCHEMBL21354647 0.84 KCNQ3 (0.35) MEN1HPGDKMT2ANPSR1RORC
SCHEMBL27254418 0.82 JAK2 (0.33) HPGDRORC
SCHEMBL21354733 0.81 JAK2 (0.33) ARCETPRORCPDK1PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11724990-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 MEN1 1284/4885HPGD 4074/4885KMT2A 736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.