Pranoprofen

Pranoprofen

SCHEMBL26008

CC(C(=O)O)c1ccc2c(c1)Cc1cccnc1O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 1.00
ABCC4 O15439 1/20 1.00
PTGS2 P35354 4/20 0.46
AKR1C3 P42330 4/20 0.40
AKR1C2 P52895 4/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
OPRK1 P41145 1/20 0.40
PDE4D Q08499 1/20 0.40
LMNA P02545 1/20 0.38
CHRM1 P11229 1/20 0.36
MEN1 O00255 1/20 0.36
FABP2 P12104 1/20 0.36
TSHR P16473 1/20 0.36
AKR1C4 P17516 1/20 0.36
ADRA2B P18089 1/20 0.36
CHRM3 P20309 1/20 0.36
HTR2C P28335 1/20 0.36
DRD3 P35462 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pranoprofen SCHEMBL30315839 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL5936565 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL30509656 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL25783945 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL29652156 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL29385910 1.00 PTGS1 (1.00) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL29089048 0.99 PTGS1 (0.98) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL28338444 0.99 PTGS1 (0.98) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL8078191 0.99 PTGS1 (0.98) PTGS1ABCC4PTGS2AKR1C3AKR1C2
Pranoprofen SCHEMBL29157937 0.94 PTGS1 (0.89) PTGS1ABCC4PTGS2AKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17611 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075537-A Application of graphene- (RADA-IKVAV) -pranoprofen, eye drops and preparation method 2026-05-26 CN claimed
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-4662203-A1 BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS Translatum Medicus Inc. (CA) 2025-12-17 EP claimed
EP-4628080-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Jeil Pharmaceutical Co., Ltd. (KR) 2025-10-08 EP claimed
US-20250281395-A1 OPHTHALMIC PREPARATION FOR TREATING MACULAR EDEMA, OPTIC NEURITIS AND NON-INFECTIOUS ENDOPHTHALMITIS THROUGH EYE DROP ADMINISTRATION Chengdu Ruimu Biopharmaceuticals Co., Ltd. (CN) 2025-09-11 US claimed
EP-3795141-B1 SOLID SOLUTION COMPOSITIONS INFIRST HEALTHCARE LTD (GB) 2025-07-30 EP claimed
WO-2025127999-A1 METHODS OF TREATING CHRONIC WOUNDS USING CASPASE INHIBITORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2025-06-19 WO claimed
CN-120154567-A Pranoprofen temperature-sensitive gel for treating xerophthalmia and preparation method thereof 贵州医科大学 2025-06-17 CN claimed
EP-4561700-A1 OPHTHALMIC SUSPENSION VEHICLES AND RELATED METHODS FOR PHARMACEUTICAL INGREDIENT DELIVERY Willis, Timothy R. (US) 2025-06-04 EP claimed
CN-118812551-B Synthesis preparation process of pranoprofen 盐城凯利药业有限公司 2025-05-30 CN claimed
US-4525348-A Pranoprofen gelled ointment YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1985-06-25 US claimed
WO-1985002542-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE ABRAHAM 1985-06-20 WO claimed
US-4522826-A SYNERGISTIC MIXTURES RICHARDSON-VICKS INC. (US) 1985-06-11 US claimed
EP-0143109-A1 Pranoprofen gelled ointment Yoshitomi Pharmaceutical Industries, Ltd. (JP) 1985-06-05 EP claimed
US-4486436-A Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same ANALGESIC ASSOCIATES (US) 1984-12-04 US claimed
EP-0114886-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. SUNSHINE ABRAHAM (US) 1984-08-08 EP claimed
US-4455146-A THERMOPLASTIC ELASTOMERS, OILS OR FATTY ACID, TACKFIER, AND A MEDICINE HISAMITSU PHARMACEUTICAL CO., LTD. (JP) 1984-06-19 US claimed
WO-1984000490-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME SUNSHINE ABRAHAM 1984-02-16 WO claimed
EP-0072462-A2 Pharmaceutical preparations Toko Yakuhin Industry Co., Ltd. (JP) 1983-02-23 EP claimed
US-3931205-A ANTIRHEUMATIC, ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1976-01-06 US claimed