Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pranoprofen SCHEMBL26008 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL30315839 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL5936565 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL30509656 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL25783945 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL29385910 | 1.00 | PTGS1 (1.00) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL29089048 | 0.99 | PTGS1 (0.98) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL28338444 | 0.99 | PTGS1 (0.98) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL8078191 | 0.99 | PTGS1 (0.98) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 | |
| Pranoprofen SCHEMBL29157937 | 0.94 | PTGS1 (0.89) | PTGS1ABCC4PTGS2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113429414-B | Preparation method of pranoprofen impurity | 海南碧凯药业有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-113429414-B | Preparation method of pranoprofen impurity | 海南碧凯药业有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114544817-A | Detection method for pranoprofen eye drops related substances | 杭州新博思生物医药有限公司 | 2022-05-27 | — | — | CN | disclosed |