Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22074993 | 0.79 | GRM5 (0.47) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL22102477 | 0.77 | GRM5 (0.42) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL22075181 | 0.77 | ALDH1A1 (0.45) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL1997041 | 0.77 | ALDH1A1 (0.45) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL2008467 | 0.77 | ALDH1A1 (0.45) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL28546795 | 0.76 | ALDH1A1 (0.43) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL27619884 | 0.76 | ALDH1A1 (0.43) | GRM5KCNH2ALDH1A1CYP3A4MAPT | |
| SCHEMBL1703616 | 0.70 | BACE1 (0.52) | ALDH1A1CYP3A4MAPTKDM4EHSP90AA1 | |
| SCHEMBL22075092 | 0.70 | NR4A2 (0.43) | GRM5KCNH2HTTNPC1RAB9A | |
| SCHEMBL30099834 | 0.69 | ALDH1A1 (0.67) | ALDH1A1CYP3A4MAPTKDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11730720-B2 | ALK5 inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11730720-B2 | ALK5 inhibitors | ALK, ACVR1, ACVRL1 | GRM5 981/4885KCNH2 3131/4885ALDH1A1 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.