Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | PAK4 | O96013 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | LTK | P29376 | 1/20 | 0.68 |
| ▸ | GRK5 | P34947 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098077 | 0.80 | NUDT1 (0.60) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL29665034 | 0.77 | JAK2 (0.78) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL2601272 | 0.76 | CCNK (0.47) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL13885299 | 0.76 | JAK2 (0.63) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL2601265 | 0.74 | JAK2 (0.63) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL12471811 | 0.74 | ALDH1A1 (0.48) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL13885309 | 0.73 | JAK2 (0.61) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL13885395 | 0.73 | JAK2 (0.61) | JAK3JAK2DAPK3PRKD3MAP4K4 | |
| SCHEMBL14646782 | 0.72 | BTK (0.61) | PDGFRBKDRBTK | |
| SCHEMBL28212089 | 0.72 | JAK2 (0.59) | JAK3JAK2DAPK3PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-24 | — | — | US | disclosed |
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
| EP-2079740-B1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMA (US) | 2012-12-05 | — | — | EP | disclosed |
| EP-2079740-B1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMA (US) | 2012-12-05 | — | — | EP | disclosed |
| US-8163732-B2 | Tricyclic heteroaryl compounds useful as inhibitors of Janus kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163732-B2 | Tricyclic heteroaryl compounds useful as inhibitors of Janus kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100081645-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081645-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| CN-101568540-A | Tricyclic heteroaryl compounds useful as JANUS kinase inhibitors | VERTEX PHARMA (US) | 2009-10-28 | — | — | CN | disclosed |
| WO-2008079521-A2 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | JAK2, JAK1, JAK3 | JAK3 3/4885JAK2 1/4885DAPK3 203/4885 |
| US-20100081645-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | JAK2, JAK1, JAK3 | JAK3 3/4885JAK2 1/4885DAPK3 203/4885 |
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | JAK2, JAK1, JAK3 | JAK3 3/4885JAK2 1/4885DAPK3 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.