Sugi Predict

Sugi Predict / Compounds / SCHEMBL2601348

SCHEMBL2601348

SCHEMBL2601348

CCOC(=O)c1cccc(Cl)c1C

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.63
▸ ALDH1A1 P00352 3/20 0.55
▸ HSD17B10 Q99714 1/20 0.54
▸ CDC25B P30305 2/20 0.50
▸ CYP4F2 P78329 1/20 0.50
▸ CYP4A11 Q02928 1/20 0.50
▸ CA12 O43570 1/20 0.50
▸ CA1 P00915 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ CA7 P43166 1/20 0.50
▸ CA9 Q16790 1/20 0.50
▸ CA14 Q9ULX7 1/20 0.50
▸ BAZ2B Q9UIF8 1/20 0.50
▸ BAZ2A Q9UIF9 1/20 0.50
▸ METTL3 Q86U44 1/20 0.49
▸ CYP1A2 P05177 2/20 0.49
▸ MAPT P10636 3/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ UTS2R Q9UKP6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20267210 0.88 ALDH1A1 (0.64) TSHRALDH1A1HSD17B10UTS2RMAPK1
SCHEMBL11418791 0.86 TSHR (0.63) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL406428 0.85 TSHR (0.74) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL4625495 0.84 TSHR (0.61) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL30093973 0.84 CYP4F2 (0.55) TSHRALDH1A1HSD17B10CYP4F2CYP4A11
SCHEMBL5749832 0.83 TSHR (0.59) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL17420759 0.83 ALDH1A1 (0.53) TSHRALDH1A1CYP1A2MAPTMEN1
SCHEMBL22853326 0.83 TSHR (0.59) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL22206861 0.83 TSHR (0.59) TSHRALDH1A1HSD17B10CDC25BCYP4F2
SCHEMBL14294533 0.83 TSHR (0.59) TSHRALDH1A1HSD17B10CDC25BCYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12030857-B2 Glucose uptake inhibitors KADMON CORPORATION, LLC (US) 2024-07-09 — — US disclosed
WO-2023048034-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING ETHYNYL GROUP 東レ・ファインケミカル株式会社 2023-03-30 — — WO disclosed
US-20200339565-A1 PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE SHIONOGI & CO., LTD. (JP) 2020-10-29 — — US disclosed
CN-107207464-B Substituted dihydro-isoquinoline ketone compound 辉瑞大药厂 2019-10-22 — — CN disclosed
US-20190248785-A1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG SHIONOGI & CO., LTD. (JP) 2019-08-15 — — US disclosed
US-10202379-B2 Substituted polycyclic carbamoyl pyridone derivative prodrug SHIONOGI & CO., LTD. (JP) 2019-02-12 — — US disclosed
EP-2620436-B1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG SHIONOGI & CO (JP) 2018-05-09 — — EP disclosed
EP-2444400-B1 SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE SHIONOGI & CO (JP) 2018-03-28 — — EP disclosed
US-20170349587-A1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG SHIONOGI & CO., LTD. (JP) 2017-12-07 — — US disclosed
US-20170349587-A1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG SHIONOGI & CO., LTD. (JP) 2017-12-07 — — US disclosed
WO-2010147068-A1 SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE 塩野義製薬株式会社 (JP) 2010-12-23 — — WO disclosed
US-20100099713-A1 2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC. (US) 2010-04-22 — — US disclosed
CN-1082790-C Herbicides RHONE POULENE AGRICULTURE LTD (GB) 2002-04-17 — — CN disclosed
CN-1100261-A Herbicides RHONE POULENC AGRICULTURE (GB) 1995-03-22 — — CN disclosed
US-5332755-A Leukotriene antagonists as antiinflammatory agents and antiallergens BAYER AKTIENGESELLSCHAFT (DE) 1994-07-26 — — US disclosed
US-5118700-A Leukotriene antagonist BAYER AKTIENGESELLSCHAFT (DE) 1992-06-02 — — US disclosed
US-4816591-A 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives AMERICAN HOECHST CORPORATION (US) 1989-03-28 — — US disclosed
US-4585788-A 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives AMERICAN HOECHST CORPORATION (US) 1986-04-29 — — US disclosed
US-4397790-A PLANT SAFENING AGENTS MONSANTO COMPANY (US) 1983-08-09 — — US disclosed
US-4082850-A TOPICAL APPLICATION OF A 6,11-DIHYDROBENZ(B,E)OXEPIN-ALKANOIC ACID OR DERIVATIVES THEREOF AMERICAN HOECHST CORPORATION (US) 1978-04-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030857-B2 Glucose uptake inhibitors SLC2A1, SLC2A4, SLC2A2 TSHR 3168/4885ALDH1A1 1422/4885HSD17B10 749/4885
US-20190248785-A1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG PREP, UNG, DPP4 TSHR 3454/4885ALDH1A1 1564/4885HSD17B10 1241/4885
US-20170349587-A1 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG PREP, UNG, DPP4 TSHR 3454/4885ALDH1A1 1564/4885HSD17B10 1241/4885
US-20100099713-A1 2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS GCKR, GCK, GALK1 TSHR 3256/4885ALDH1A1 820/4885HSD17B10 2921/4885
US-20200339565-A1 PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PREP, UNG, DPP4 TSHR 3454/4885ALDH1A1 1478/4885HSD17B10 1132/4885
US-10202379-B2 Substituted polycyclic carbamoyl pyridone derivative prodrug PREP, UNG, DPP4 TSHR 3454/4885ALDH1A1 1564/4885HSD17B10 1241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.