Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | PRCP | P42785 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26004738 | 0.87 | SIGMAR1 (0.46) | SIGMAR1OPRL1 | |
| SCHEMBL26004428 | 0.85 | SIGMAR1 (0.48) | SIGMAR1GAA | |
| SCHEMBL26013583 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCPGAA | |
| SCHEMBL26004593 | 0.83 | PRCP (0.38) | SIGMAR1PRCP | |
| SCHEMBL26014211 | 0.83 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL26014113 | 0.82 | SIGMAR1 (0.43) | SIGMAR1OPRL1 | |
| SCHEMBL26004354 | 0.81 | SIGMAR1 (0.49) | SIGMAR1PRCP | |
| SCHEMBL26004590 | 0.81 | SIGMAR1 (0.46) | SIGMAR1PRCP | |
| SCHEMBL26014956 | 0.80 | SIGMAR1 (0.46) | SIGMAR1PRCP | |
| SCHEMBL26004665 | 0.80 | SIGMAR1 (0.50) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |