Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601694 | 0.90 | NPY5R (0.41) | TP53EPHX2GNRHRALDH1A1SMN1; SMN2 | |
| SCHEMBL2601907 | 0.88 | ALDH1A1 (0.40) | EPHX2GNRHRALDH1A1MAPT | |
| SCHEMBL2600313 | 0.86 | ALDH1A1 (0.46) | TP53ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL11936169 | 0.83 | ALDH1A1 (0.39) | TP53ALDH1A1MAPT | |
| SCHEMBL2600321 | 0.83 | EPHX2 (0.56) | EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2600311 | 0.76 | NPY5R (0.43) | TP53ALDH1A1MAPTKDM4E | |
| SCHEMBL2600316 | 0.76 | NPY5R (0.43) | TP53ALDH1A1MAPTKDM4E | |
| SCHEMBL2600317 | 0.74 | NPY5R (0.41) | TP53ALDH1A1MAPT | |
| SCHEMBL11936164 | 0.74 | NPY5R (0.42) | TP53ALDH1A1 | |
| SCHEMBL2600307 | 0.73 | NPY5R (0.46) | ALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372833-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20120095231-A1 | UREA DERIVATIVE | YANO TOSHISADA (JP) | 2012-04-19 | — | — | US | disclosed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | disclosed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095231-A1 | UREA DERIVATIVE | NPY5R, NPY1R, NPY2R | TP53 3688/4885EPHX2 4211/4885GNRHR 83/4885 |
| US-20090203712-A1 | Urea Derivative | NPY5R, NPY1R, NPY2R | TP53 3658/4885EPHX2 4206/4885GNRHR 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.