Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.62 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 8/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307652 | 0.89 | BACE1 (0.62) | BACE1TRPM8BCHECTSDCTSB | |
| SCHEMBL8708340 | 0.89 | TRPM8 (0.60) | BACE1SLC6A11TRPM8CTSDCTSB | |
| SCHEMBL24324236 | 0.88 | TRPM8 (0.56) | BACE1SLC6A11TRPM8BCHECTSD | |
| SCHEMBL7698179 | 0.88 | TRPM8 (0.56) | BACE1SLC6A11TRPM8BCHECTSD | |
| SCHEMBL4910315 | 0.88 | TRPM8 (0.56) | BACE1SLC6A11TRPM8BCHECTSD | |
| SCHEMBL5413813 | 0.88 | TRPM8 (0.56) | BACE1SLC6A11TRPM8BCHECTSD | |
| SCHEMBL10570700 | 0.86 | CTSK (0.54) | TRPM8CTSB | |
| SCHEMBL13219392 | 0.86 | TRPM8 (0.59) | TRPM8CTSDCTSBCTRB1 | |
| SCHEMBL8268242 | 0.86 | TRPM8 (0.59) | TRPM8CTSDCTSBCTRB1 | |
| SCHEMBL4908808 | 0.84 | SPPL2A (0.53) | BACE1SLC6A11TRPM8BCHECTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163953-B2 | Compounds for lysosomal modulation and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163953-B2 | Compounds for lysosomal modulation and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090281178-A1 | Compounds for Lysosomal Modulation and Methods of Use | UNIVERSITY OF CONNECTICUT | 2009-11-12 | — | — | US | disclosed |
| US-20090281178-A1 | Compounds for Lysosomal Modulation and Methods of Use | UNIVERSITY OF CONNECTICUT | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281178-A1 | Compounds for Lysosomal Modulation and Methods of Use | GAA, GBA1, CTSA | BACE1 35/4885SLC6A11 1654/4885TRPM8 2577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.