Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601891 | 0.89 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2MAPK1TP53 | |
| SCHEMBL2601694 | 0.76 | NPY5R (0.41) | ALDH1A1SMN1; SMN2TP53MAPTPOLB | |
| SCHEMBL2600316 | 0.71 | NPY5R (0.43) | KDM4EALDH1A1TP53MAPTTSHR | |
| SCHEMBL2600321 | 0.71 | EPHX2 (0.56) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2600307 | 0.71 | NPY5R (0.46) | KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2601907 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBTSHR | |
| SCHEMBL11936164 | 0.67 | NPY5R (0.42) | ALDH1A1TP53TSHR | |
| SCHEMBL2600313 | 0.67 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPK1TP53 | |
| SCHEMBL2600317 | 0.66 | NPY5R (0.41) | ALDH1A1TP53MAPTTSHR | |
| SCHEMBL2600331 | 0.66 | NPY5R (0.44) | ALDH1A1SMN1; SMN2TP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372833-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20120095231-A1 | UREA DERIVATIVE | YANO TOSHISADA (JP) | 2012-04-19 | — | — | US | disclosed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | disclosed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095231-A1 | UREA DERIVATIVE | NPY5R, NPY1R, NPY2R | KDM4E 2072/4885ALDH1A1 4384/4885SMN1; SMN2 3305/4885 |
| US-20090203712-A1 | Urea Derivative | NPY5R, NPY1R, NPY2R | KDM4E 2024/4885ALDH1A1 4390/4885SMN1; SMN2 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.