Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26018931 | 1.00 | F2 (0.41) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL25796422 | 0.86 | F2 (0.47) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL26497408 | 0.82 | HTR3E (0.43) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL26019479 | 0.82 | CHRNA7 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL26019255 | 0.82 | CHRNA7 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL29346476 | 0.82 | CHRNA7 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11061761 | 0.78 | TSHR (0.47) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL26545466 | 0.78 | F2 (0.45) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL25845894 | 0.78 | F2 (0.45) | F2LMNACHRNA7HTR3EHTR3B | |
| SCHEMBL28781857 | 0.77 | KMT2A (0.44) | F2LMNACHRNA7HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974420-B1 | N-ALKYLARYL-5-OXYHETEROARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | NOVARTIS AG (CH) | 2023-08-16 | — | — | EP | disclosed |