Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270860 | 0.86 | — | — | |
| SCHEMBL24136411 | 0.86 | GRIN2B (0.46) | GRIN2BGRIN1 | |
| SCHEMBL24270948 | 0.82 | GRIN2B (0.48) | GRIN2BGRIN1 | |
| SCHEMBL24270944 | 0.75 | — | — | |
| SCHEMBL26020752 | 0.74 | GRIN2B (0.45) | KDM4EGRIN2BGRIN1 | |
| SCHEMBL22239315 | 0.74 | GRIN2B (0.45) | KDM4EGRIN2BGRIN1 | |
| SCHEMBL24136404 | 0.73 | GRIN2B (0.37) | GRIN2BGRIN1 | |
| SCHEMBL24270900 | 0.68 | GRIN2B (0.51) | GRIN2BGRIN1 | |
| SCHEMBL22239234 | 0.65 | — | — | |
| SCHEMBL22239312 | 0.64 | OPRD1 (0.31) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683207-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Cadent Therapeutics, Inc. (US) | 2020-07-22 | — | — | EP | disclosed |