Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 4/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | TYMS | P04818 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26026689 | 0.89 | RARG (0.50) | RARGPARP1LMNAARCHEK1 | |
| SCHEMBL26027584 | 0.86 | RARG (0.42) | RARGPARP1LMNATSHRTNKS | |
| SCHEMBL26026865 | 0.86 | RARG (0.44) | RARGPARP1LMNAARCHEK1 | |
| SCHEMBL22077248 | 0.82 | RARG (0.50) | RARGPARP1LMNATSHRAR | |
| SCHEMBL29578026 | 0.82 | RARG (0.50) | RARGPARP1LMNATSHRAR | |
| SCHEMBL24375457 | 0.77 | THRB (0.36) | RARGLMNATSHRDRD1THRA | |
| SCHEMBL26027125 | 0.77 | RARG (0.39) | RARGLMNAARTYMSHTT | |
| SCHEMBL22108436 | 0.76 | THRA (0.58) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL25430197 | 0.76 | GAA (0.42) | RARGPARP1DRD1PARP2THRA | |
| SCHEMBL26027437 | 0.75 | RARG (0.33) | RARGPARP1THRATHRBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154842-A1 | THR BETA ANALOGS AND USES THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |