Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25778111 | 0.74 | HTT (0.47) | HTTPTK2PDPK1CHEK1AURKA | |
| SCHEMBL570694 | 0.74 | HTT (0.38) | HTTPTK2 | |
| SCHEMBL2748854 | 0.73 | TP53 (0.46) | HTTPTK2ALDH1A1PDPK1CHEK1 | |
| SCHEMBL4839832 | 0.69 | HTT (0.38) | HTTPTK2 | |
| SCHEMBL5384173 | 0.69 | DYRK1A (0.48) | HTTPTK2ALDH1A1 | |
| SCHEMBL397509 | 0.69 | PI4KA (0.50) | HTTPTK2PDPK1CHEK1AURKA | |
| SCHEMBL10226489 | 0.69 | ALDH1A1 (0.56) | ALDH1A1PDPK1CHEK1AURKA | |
| SCHEMBL2760379 | 0.69 | DYRK1A (0.53) | — | |
| SCHEMBL21347892 | 0.69 | HTT (0.38) | HTTPTK2PDPK1CHEK1AURKA | |
| SCHEMBL12462960 | 0.69 | HTT (0.38) | HTTPTK2ALDH1A1PDPK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271960-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | PLIANT THERAPEUTICS INC (US) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271960-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | ITGB6, ITGA6, ITGA5 | HTT 4570/4885PTK2 91/4885ALDH1A1 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.