Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.32 |
| ▸ | POLRMT | O00411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144215 | 0.83 | DOT1L (0.33) | DOT1LPOLRMT | |
| SCHEMBL24058355 | 0.83 | DOT1L (0.33) | DOT1LPOLRMT | |
| SCHEMBL24057850 | 0.79 | DOT1L (0.31) | DOT1L | |
| SCHEMBL24058368 | 0.79 | DOT1L (0.31) | DOT1L | |
| SCHEMBL24149121 | 0.78 | DOT1L (0.34) | DOT1L | |
| SCHEMBL22355531 | 0.77 | POLRMT (0.43) | DOT1LPOLRMT | |
| SCHEMBL24606310 | 0.77 | DOT1L (0.36) | DOT1LPOLRMT | |
| SCHEMBL24340458 | 0.77 | POLRMT (0.43) | DOT1LPOLRMT | |
| SCHEMBL24058306 | 0.77 | POLRMT (0.35) | DOT1LPOLRMT | |
| SCHEMBL24606327 | 0.76 | DOT1L (0.34) | DOT1LPOLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219513-A1 | CRYSTALLINE FORM OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5-(4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN2-YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | Gilead Sciences, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |