Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.64 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | OSBP | P22059 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.59 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 5/20 | 0.56 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | UGCG | Q16739 | 2/20 | 0.53 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | CRYAB | P02511 | 1/20 | 0.53 |
| ▸ | HMGCR | P04035 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25835344 | 1.00 | POLA1 (0.64) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL15702072 | 0.99 | POLA1 (0.63) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL17665326 | 0.99 | POLA1 (0.63) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL26032472 | 0.99 | POLA1 (0.63) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL26041071 | 0.97 | POLA1 (0.60) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL24341653 | 0.96 | POLA1 (0.68) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL25835317 | 0.96 | POLA1 (0.68) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL26172664 | 0.95 | POLA1 (0.67) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL15686572 | 0.94 | CYP46A1 (0.67) | POLA1CYP46A1USP2OSBPRORC | |
| SCHEMBL30390458 | 0.94 | CYP46A1 (0.67) | POLA1CYP46A1USP2OSBPRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265429-A1 | SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF | Arrowhead Pharmaceuticals, Inc. | 2023-08-24 | — | — | US | disclosed |
| US-20230265429-A1 | SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF | Arrowhead Pharmaceuticals, Inc. | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265429-A1 | SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF | MUSK, MYLK2, TNNC1 | POLA1 2871/4885CYP46A1 4314/4885USP2 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.