Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPRZ1 | P23471 | 3/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.30 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698779 | 0.81 | SMN1; SMN2 (0.45) | KDM4EALDH1A1TDP1PDE2ASMN1; SMN2 | |
| SCHEMBL24987669 | 0.80 | PDE2A (0.41) | KDM4EALDH1A1TDP1PDE2ASMN1; SMN2 | |
| SCHEMBL15108319 | 0.79 | AKR1C3 (0.36) | TDP1PDE2ALMNAGAA | |
| SCHEMBL24685170 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1PDE2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL901110 | 0.75 | SMN1; SMN2 (0.49) | KDM4EALDH1A1TDP1SMN1; SMN2PTPRZ1 | |
| SCHEMBL15097610 | 0.74 | PDE2A (0.33) | PDE2A | |
| SCHEMBL18737240 | 0.73 | SLC6A4 (0.42) | ALDH1A1PTPN1MAPT | |
| SCHEMBL84521 | 0.71 | PDE2A (0.70) | PDE2A | |
| SCHEMBL16667141 | 0.71 | KCNK2 (0.43) | KDM4EALDH1A1TDP1SMN1; SMN2PTPRZ1 | |
| SCHEMBL3627129 | 0.71 | ALDH1A1 (0.54) | KDM4EALDH1A1TDP1PDE2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802127-B2 | 3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors | PFIZER INC. (US) | 2023-10-31 | — | — | US | disclosed |
| US-11691973-B2 | 3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors | PFIZER INC. (US) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691973-B2 | 3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors | NRAS, KRAS, MAPK1 | KDM4E 302/4885ALDH1A1 701/4885TDP1 1011/4885 |
| US-11802127-B2 | 3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors | NRAS, KRAS, MAPK1 | KDM4E 302/4885ALDH1A1 701/4885TDP1 1011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.