Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020999 | 0.88 | P4HTM (0.59) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1020185 | 0.88 | MAPK1 (0.59) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL71905 | 0.83 | NNMT (1.00) | NNMTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL29975550 | 0.83 | NNMT (1.00) | NNMTSMN1; SMN2MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL6234386 | 0.81 | NNMT (0.96) | NNMTSMN1; SMN2KDM4EMAPTMKNK1 | |
| Hydrochloric Acid SCHEMBL5013391 | 0.81 | NNMT (0.96) | NNMTSMN1; SMN2KDM4EMAPTMKNK1 | |
| SCHEMBL3788719 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5013528 | 0.79 | NNMT (0.84) | NNMTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL22773569 | 0.78 | KMT2A (0.65) | NNMTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL13947158 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | NNMT 1525/4885SMN1; SMN2 4094/4885MEN1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.