Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.57 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.57 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013926 | 0.89 | ALB (0.57) | RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1 | |
| SCHEMBL26033660 | 0.86 | KMT2A (0.52) | RAB9ASMN1; SMN2MEN1KMT2ATDP1 | |
| SCHEMBL26033207 | 0.84 | HCAR3 (0.49) | RAB9AMEN1KMT2AMAPT | |
| SCHEMBL26035101 | 0.84 | ALB (0.50) | RAB9AKMT2A | |
| SCHEMBL16642301 | 0.82 | ALB (0.58) | RAB9AMEN1KMT2AMAPT | |
| SCHEMBL26037196 | 0.82 | HPGD (0.48) | RAB9AMEN1KMT2A | |
| SCHEMBL26037241 | 0.81 | ALB (0.46) | RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL26033653 | 0.81 | ALB (0.54) | MAPT | |
| SCHEMBL2303285 | 0.81 | KCNQ3 (0.80) | RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1 | |
| SCHEMBL26034744 | 0.80 | HPGD (0.57) | RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | RAB9A 761/4885SMN1; SMN2 4094/4885KCNQ3 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.