Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26581649 | 0.87 | MCL1 (0.38) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL26581456 | 0.86 | ALDH1A1 (0.40) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL23809535 | 0.85 | KDM4E (0.36) | KDM4EGPR35MCL1HCAR3ALDH1A1 | |
| SCHEMBL26036872 | 0.83 | MCL1 (0.37) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL6703975 | 0.75 | ALDH1A1 (0.42) | KDM4EGPR35ALDH1A1HPGDHSD17B10 | |
| SCHEMBL26581694 | 0.75 | ALDH1A1 (0.44) | KDM4EMCL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL26581713 | 0.74 | CCR2 (0.37) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL26590807 | 0.73 | ALDH1A1 (0.38) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL26581225 | 0.73 | HSD17B10 (0.51) | KDM4EGPR35MCL1ALDH1A1HPGD | |
| SCHEMBL23809272 | 0.73 | MCL1 (0.35) | KDM4EGPR35MCL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| EP-3423435-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2023-08-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885GPR35 3148/4885MCL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.