Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | ACACA | Q13085 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809400 | 0.87 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1HPGDGLRA1TSHR | |
| SCHEMBL23809313 | 0.82 | HSD17B10 (0.46) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL23809267 | 0.81 | HRH3 (0.43) | HPGDALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL23809170 | 0.75 | HSD17B10 (0.47) | HPGDALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL23809290 | 0.70 | KDM4E (0.54) | HPGDTSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL23809525 | 0.70 | HRH3 (0.41) | HPGDALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL23809497 | 0.68 | ALDH1A1 (0.36) | HSP90AA1HSP90AB1HPGDALDH1A1KDM4E | |
| SCHEMBL26037572 | 0.68 | HRH3 (0.39) | HPGDALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL23809489 | 0.68 | HSD17B10 (0.46) | HPGDALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL23809365 | 0.68 | F2 (0.38) | HSP90AA1HPGDALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423435-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2023-08-23 | — | — | EP | disclosed |