Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26039645 | 0.87 | SIGMAR1 (0.33) | — | |
| SCHEMBL26039316 | 0.85 | SIGMAR1 (0.31) | — | |
| SCHEMBL26039646 | 0.85 | — | — | |
| SCHEMBL26039319 | 0.84 | OPRL1 (0.31) | — | |
| SCHEMBL26039578 | 0.84 | — | — | |
| SCHEMBL26039260 | 0.84 | OPRL1 (0.31) | — | |
| SCHEMBL26039381 | 0.84 | OPRL1 (0.31) | — | |
| SCHEMBL26039573 | 0.83 | SIGMAR1 (0.31) | — | |
| SCHEMBL25357235 | 0.82 | SIGMAR1 (0.34) | — | |
| SCHEMBL25357848 | 0.82 | SIGMAR1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |