Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16195562 | 0.87 | ALOX5 (0.52) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL28503483 | 0.77 | AURKA (0.44) | KDM4ETSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL3872064 | 0.72 | KDM4E (0.45) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL31752914 | 0.72 | KDM4E (0.45) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL10661545 | 0.72 | KDM4E (0.45) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL31562070 | 0.72 | KDM4E (0.45) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL23143494 | 0.72 | ALOX5 (0.58) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL16260461 | 0.72 | ALOX5 (0.58) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL1201834 | 0.72 | MYC (0.44) | ALOX5KDM4EPOLBATMLMNA | |
| SCHEMBL31726046 | 0.71 | ALOX5 (0.47) | ALOX5KDM4EPOLBATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| CN-112074511-A | Substituted benzodiazoles and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2020-12-11 | — | — | CN | disclosed |