Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31610082 | 1.00 | HPGD (0.61) | HPGDDHX9MAPK14KDM4ETDP1 | |
| SCHEMBL27681315 | 0.82 | KCNK3 (0.72) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL31610145 | 0.82 | KCNK3 (0.72) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL30543903 | 0.80 | HPGD (0.65) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL25368211 | 0.80 | HPGD (0.65) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL31610059 | 0.80 | HPGD (0.55) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL31610066 | 0.80 | HPGD (0.55) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL26043564 | 0.78 | EPHX2 (0.59) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL26043484 | 0.77 | HPGD (0.61) | HPGDDHX9KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL27179484 | 0.77 | ADRB2 (0.67) | ADRB2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |