Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.59 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26043484 | 0.82 | HPGD (0.61) | DHX9HPGDRAB9ANPC1MAPT | |
| SCHEMBL31610145 | 0.80 | KCNK3 (0.72) | DHX9HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27681315 | 0.80 | KCNK3 (0.72) | DHX9HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31610077 | 0.80 | MAPT (0.65) | HPGDRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2347217 | 0.79 | MAPK14 (0.61) | RAB9ANPC1TP53PKMMAPK1 | |
| SCHEMBL4256420 | 0.79 | RAB9A (0.78) | RAB9ANPC1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL26043351 | 0.79 | GAA (0.55) | DHX9HPGDRAB9ANPC1MAPT | |
| SCHEMBL4251987 | 0.79 | RAB9A (0.85) | HPGDRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL25368211 | 0.78 | HPGD (0.65) | DHX9HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30543903 | 0.78 | HPGD (0.65) | DHX9HPGDSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250179013-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. | 2025-06-05 | — | — | US | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179013-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | DHX9, DHX29, DDX39B | EPHX2 628/4885NR1H4 2542/4885DHX9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.