Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857649 | 0.85 | LMNA (0.78) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857623 | 0.81 | LMNA (0.71) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857608 | 0.81 | LMNA (0.71) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857637 | 0.80 | KDM4E (0.71) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857579 | 0.80 | LMNA (0.70) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857601 | 0.79 | LMNA (0.79) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857582 | 0.79 | LMNA (0.68) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL28857594 | 0.77 | LMNA (0.76) | LMNAKDM4EPOLBKMT2AHTT | |
| SCHEMBL25432419 | 0.76 | AURKA (0.59) | KMT2AMEN1DHX9 | |
| SCHEMBL28857664 | 0.76 | KDM4E (0.68) | LMNAKDM4EPOLBKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |