Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857649 | 0.93 | LMNA (0.78) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857601 | 0.87 | LMNA (0.79) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857608 | 0.86 | LMNA (0.71) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857637 | 0.86 | KDM4E (0.71) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857622 | 0.85 | POLB (0.64) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857582 | 0.84 | LMNA (0.68) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857594 | 0.83 | LMNA (0.76) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857623 | 0.82 | LMNA (0.71) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857664 | 0.82 | KDM4E (0.68) | LMNAKDM4EHTTPOLBKMT2A | |
| SCHEMBL28857633 | 0.81 | KDM4E (0.67) | LMNAKDM4EHTTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | claimed |
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | disclosed |