Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25369921 | 0.84 | MAPT (0.60) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL30543969 | 0.84 | MAPT (0.60) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL30543924 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL25367000 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL30544018 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL26043694 | 0.82 | ESRRG (0.61) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL30543881 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2HSD17B1HSD17B2MAPTALDH1A1 | |
| SCHEMBL25366544 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2HSD17B1HSD17B2MAPTALDH1A1 | |
| SCHEMBL6870004 | 0.78 | HSD17B1 (0.64) | NPC1RAB9ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL810105 | 0.76 | RXFP1 (0.76) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |