Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.64 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.64 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | ATP4A | P20648 | 1/20 | 0.47 |
| ▸ | ATP4B | P51164 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457495 | 0.82 | ABL1 (0.52) | HSD17B1HSD17B2HDAC6 | |
| SCHEMBL30916784 | 0.78 | TUBB4A (0.58) | HSD17B1HSD17B2MAPTHTT | |
| SCHEMBL26044573 | 0.78 | NPC1 (0.55) | HSD17B1HSD17B2ALDH1A1HSD17B10LMNA | |
| SCHEMBL5605556 | 0.77 | HDAC6 (0.62) | IKBKBPLAUHDAC6 | |
| SCHEMBL5613367 | 0.77 | HDAC6 (0.71) | HSD17B1HSD17B2PARP1IKBKBHDAC6 | |
| SCHEMBL1690557 | 0.76 | PARP1 (0.80) | HSD17B2PARP1IKBKBHDAC4HDAC8 | |
| SCHEMBL1981372 | 0.76 | ALDH1A1 (0.52) | HSD17B1HSD17B2ALDH1A1HSD17B10LMNA | |
| SCHEMBL25399545 | 0.76 | KMT2A (0.54) | PARP1IKBKBMAPTCDK2IKBKE | |
| SCHEMBL4995249 | 0.75 | PLAU (0.67) | HSD17B2PARP1HDAC4HDAC8PLG | |
| SCHEMBL30958376 | 0.75 | PLAU (0.67) | HSD17B2PARP1HDAC4HDAC8PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394159-A1 | New thiophene derivatives, process for their preparation and pharmaceutical compositions containing them | Warner-Lambert Company LLC (US) | 2004-03-03 | — | — | EP | claimed |