Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28123366 | 0.85 | POLB (0.54) | POLBNPSR1EGFRLCKTYR | |
| SCHEMBL26046404 | 0.84 | IAPP (0.46) | CHRNA7 | |
| SCHEMBL4885810 | 0.84 | POLB (0.49) | POLBNPSR1EGFRLCKTYR | |
| SCHEMBL490884 | 0.82 | EGFR (0.57) | POLBNPSR1EGFRLCKTYR | |
| SCHEMBL490491 | 0.81 | POLB (0.67) | POLBTYR | |
| SCHEMBL29998634 | 0.81 | POLB (0.67) | POLBTYR | |
| SCHEMBL1789904 | 0.80 | TYR (0.57) | POLBNPSR1TYR | |
| SCHEMBL3652088 | 0.79 | POLB (0.51) | POLBNPSR1TYRCHRNA7FFAR1 | |
| SCHEMBL7102470 | 0.78 | NPSR1 (0.66) | POLBNPSR1FFAR1FFAR4 | |
| SCHEMBL18075760 | 0.78 | POLB (0.46) | POLBNPSR1EGFRLCKFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |