Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.61 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.61 |
| ▸ | IAPP | P10997 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434948 | 0.85 | IAPP (0.58) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL269353 | 0.83 | IAPP (0.72) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL29934495 | 0.83 | IAPP (0.72) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL3728799 | 0.81 | CYP4F2 (0.58) | CYP4F2CYP4A11SMN1; SMN2MAPTFFAR1 | |
| SCHEMBL6296852 | 0.80 | CYP4F2 (0.57) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL29843018 | 0.79 | IAPP (0.56) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL1404957 | 0.79 | IAPP (0.56) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL12225988 | 0.79 | PTGER4 (0.58) | IAPPALDH1A1LMNAMAPTIKBKB | |
| SCHEMBL8702883 | 0.79 | ALDH1A1 (0.56) | CYP4F2CYP4A11IAPPALDH1A1LMNA | |
| SCHEMBL22526147 | 0.79 | ALDH1A1 (0.51) | CYP4F2CYP4A11IAPPALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |