Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 5/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | IAPP | P10997 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046331 | 0.88 | PKM (0.49) | KDM4EAPPBACE1GAAMAPT | |
| SCHEMBL26046395 | 0.85 | KDM4E (0.53) | KDM4EFDPSAPPBACE1ABCB1 | |
| SCHEMBL26046382 | 0.83 | KDM4E (0.60) | KDM4EFDPSAPPBACE1IAPP | |
| SCHEMBL26046384 | 0.81 | IAPP (0.56) | KDM4EAPPIAPPMAPTLMNA | |
| SCHEMBL26046486 | 0.81 | CYP3A4 (0.42) | KDM4EAPPBACE1MAPTLMNA | |
| SCHEMBL26046367 | 0.81 | KDM4E (0.67) | KDM4EFDPSBACE1IAPPMAPT | |
| SCHEMBL1877093 | 0.80 | KDM4E (0.57) | KDM4EFDPSAPPIAPPABCB1 | |
| SCHEMBL1877092 | 0.80 | KDM4E (0.57) | KDM4EFDPSAPPIAPPABCB1 | |
| SCHEMBL26046381 | 0.79 | APP (0.46) | KDM4EAPPBACE1IAPPABCB1 | |
| SCHEMBL26046380 | 0.77 | KDM4E (0.57) | KDM4EFDPSAPPIAPPABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |