Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.53 |
| ▸ | TFEB | P19484 | 1/20 | 0.51 |
| ▸ | IAPP | P10997 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.45 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046298 | 0.88 | KDM4E (0.61) | KDM4ENFE2L2TFEBMAPTLMNA | |
| SCHEMBL26046447 | 0.81 | NFE2L2 (0.43) | KDM4ENFE2L2TFEBMAPTNPC1 | |
| SCHEMBL26046397 | 0.81 | KDM4E (0.53) | KDM4ENFE2L2IAPPMAPTLMNA | |
| SCHEMBL26046395 | 0.81 | KDM4E (0.53) | KDM4ENFE2L2LMNANPC1RAB9A | |
| SCHEMBL29372147 | 0.80 | KDM4E (1.00) | KDM4ENFE2L2TFEBMAPTLMNA | |
| SCHEMBL644526 | 0.80 | KDM4E (1.00) | KDM4ENFE2L2TFEBMAPTLMNA | |
| SCHEMBL644527 | 0.80 | KDM4E (1.00) | KDM4ENFE2L2TFEBMAPTLMNA | |
| SCHEMBL26046375 | 0.80 | IAPP (0.65) | KDM4ENFE2L2IAPPMAPTLMNA | |
| SCHEMBL11260285 | 0.80 | KDM4E (0.73) | KDM4ENFE2L2TFEBIAPPMAPT | |
| SCHEMBL11260283 | 0.80 | KDM4E (0.73) | KDM4ENFE2L2TFEBIAPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |