Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25434565 | 1.00 | NLRP3 (0.46) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048860 | 1.00 | NLRP3 (0.46) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL31513515 | 1.00 | NLRP3 (0.46) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048857 | 0.90 | NLRP3 (0.44) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL25434999 | 0.90 | NLRP3 (0.44) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048379 | 0.90 | NLRP3 (0.44) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048853 | 0.90 | NLRP3 (0.44) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL25433192 | 0.88 | NLRP3 (0.43) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048740 | 0.88 | NLRP3 (0.43) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 | |
| SCHEMBL26048751 | 0.88 | NLRP3 (0.43) | NLRP3ALDH1A1SMN1; SMN2TP53CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158708-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2023-08-24 | — | — | WO | disclosed |