Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2604931 | 0.95 | CYP1A2 (0.61) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL2604927 | 0.89 | MAPT (0.61) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL6498396 | 0.89 | MAPT (0.61) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL2604951 | 0.89 | CYP1A2 (0.55) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL27912687 | 0.86 | NQO2 (0.60) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL27912686 | 0.86 | NQO2 (0.60) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL11670985 | 0.83 | KDM4E (0.56) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL11670988 | 0.83 | KDM4E (0.56) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL3954692 | 0.83 | KDM4E (0.59) | BACE1KDM4EHPGDCYP1A2CYP3A4 | |
| SCHEMBL3954698 | 0.83 | KDM4E (0.59) | BACE1KDM4EHPGDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158380-B2 | Imaging agents for protein misfolding | NEW YORK UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158380-B2 | Imaging agents for protein misfolding | NEW YORK UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100279340-A1 | Imaging agents for protein misfolding | NYU (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100279340-A1 | Imaging agents for protein misfolding | NYU (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279340-A1 | Imaging agents for protein misfolding | APBA1, APP, SPG11 | BACE1 27/4885KDM4E 4232/4885HPGD 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.