Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.64 |
| ▸ | RAB9A | P51151 | 12/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.64 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2604961 | 0.85 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2TP53CASP3 | |
| SCHEMBL2604967 | 0.85 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL2604968 | 0.85 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL28642664 | 0.84 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL60680 | 0.81 | MAOA (0.74) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL14516338 | 0.79 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL12895791 | 0.79 | TP53 (0.75) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL13882259 | 0.79 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL4031243 | 0.78 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL13427308 | 0.77 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163782-B2 | 1,2,4-oxadiazole benzoic acid compositions | PTC THERAPEUTICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163782-B2 | 1,2,4-oxadiazole benzoic acid compositions | PTC THERAPEUTICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |