Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.44 |
| ▸ | MAPT | P10636 | 13/20 | 0.44 |
| ▸ | MEN1 | O00255 | 13/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26054467 | 0.86 | SMN1; SMN2 (0.47) | KMT2AMAPTMEN1ALDH1A1USP2 | |
| SCHEMBL26056683 | 0.75 | NPC1 (0.38) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL23682809 | 0.73 | HDAC6 (0.44) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL26054728 | 0.72 | MAPT (0.57) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL26054687 | 0.69 | AKR1C3 (0.48) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL14212567 | 0.69 | ALDH1A1 (0.47) | KMT2AMAPTMEN1ALDH1A1USP2 | |
| SCHEMBL23610400 | 0.69 | TDP1 (0.45) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL1960058 | 0.68 | SMN1; SMN2 (0.73) | KMT2AMAPTMEN1ALDH1A1USP2 | |
| SCHEMBL21119731 | 0.68 | HRH3 (0.60) | KMT2AALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL2625474 | 0.66 | KLK7 (0.50) | KMT2AMAPTMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | TRIM33, TRIM28, TRIM4 | KMT2A 1335/4885MAPT 1086/4885MEN1 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.