Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26056274 | 1.00 | HDAC6 (0.36) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26051957 | 0.94 | P2RX3 (0.35) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26051960 | 0.94 | P2RX3 (0.35) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26061354 | 0.89 | HDAC6 (0.35) | HDAC6HDAC3HDAC1HDAC2PRMT5 | |
| SCHEMBL26061355 | 0.89 | HDAC6 (0.35) | HDAC6HDAC3HDAC1HDAC2PRMT5 | |
| SCHEMBL26051965 | 0.85 | HDAC6 (0.33) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26051964 | 0.85 | HDAC6 (0.33) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26056261 | 0.84 | HDAC6 (0.39) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL26055853 | 0.83 | P2RX3 (0.34) | HDAC6P2RX3P2RX2HDAC3HDAC1 | |
| SCHEMBL26055748 | 0.83 | P2RX3 (0.34) | HDAC6P2RX3P2RX2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150203-A1 | HDAC6 INHIBITORS AND USES THEREOF | EIKONIZO THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |