Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2754 | 1.00 | ALOX5 (0.45) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL19458771 | 1.00 | ALOX5 (0.45) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL11234464 | 1.00 | ALOX5 (0.45) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| Hydrochloric Acid SCHEMBL13518199 | 0.97 | ALOX5 (0.43) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| Urea SCHEMBL2807369 | 0.97 | ALOX5 (0.43) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL2170733 | 0.97 | ALOX5 (0.43) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL9547539 | 0.95 | ALOX5 (0.44) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| Cyclohexylamine SCHEMBL27429394 | 0.91 | ALOX5 (0.39) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL2667248 | 0.89 | HSD11B1 (0.40) | ALOX5PHGDHHSD11B1EPHX1KDM4E | |
| SCHEMBL2606355 | 0.87 | HSD11B1 (0.39) | ALOX5PHGDHHSD11B1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |