Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 4/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 10/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104999 | 0.72 | HCAR3 (0.56) | CYP11B1CYP11B2HCAR3 | |
| SCHEMBL1570177 | 0.71 | HCAR3 (0.48) | IKBKETBK1CYP11B1CYP11B2HCAR3 | |
| SCHEMBL2571391 | 0.71 | GAA (0.40) | IKBKETBK1KDM1A | |
| SCHEMBL31199068 | 0.71 | GAA (0.40) | IKBKETBK1KDM1A | |
| SCHEMBL25359599 | 0.70 | KDM4E (0.40) | IKBKETBK1ABL1 | |
| SCHEMBL30623231 | 0.70 | KDM4E (0.40) | IKBKETBK1ABL1 | |
| SCHEMBL1570064 | 0.68 | KDM4E (0.46) | HCAR3 | |
| SCHEMBL466003 | 0.67 | RAB9A (0.46) | HCAR3 | |
| SCHEMBL14155652 | 0.67 | IKBKE (0.34) | IKBKETBK1HCAR3 | |
| SCHEMBL1727867 | 0.66 | MEN1 (0.41) | MERTKKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |