Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | PIP4K2A | P48426 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BCL6 | P41182 | 2/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26066568 | 0.90 | TNF (0.63) | TNFEPHB4 | |
| SCHEMBL26066602 | 0.86 | TNF (0.61) | TNFNPC1RAB9APIP4K2AMAPT | |
| SCHEMBL26066598 | 0.85 | TNF (0.57) | TNFGRM4PIP4K2AMAPTBCL6 | |
| SCHEMBL26066566 | 0.83 | TNF (0.60) | TNFGRM4EPHB4 | |
| SCHEMBL23624399 | 0.82 | TNF (0.62) | TNFNPC1RAB9AMAPTGAA | |
| SCHEMBL30012160 | 0.81 | TNF (0.65) | TNFGRM4MAPTGAABCL6 | |
| SCHEMBL23611044 | 0.81 | TNF (0.65) | TNFGRM4MAPTGAABCL6 | |
| SCHEMBL23624398 | 0.80 | TNF (0.75) | TNFRAB9AMAPTLMNAMEN1 | |
| SCHEMBL23624476 | 0.80 | TNF (0.48) | TNFPIP4K2ABCL6 | |
| SCHEMBL26373434 | 0.79 | PIP4K2A (0.50) | TNFNPC1RAB9AGRM4PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023155019-A1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF BAX AND/OR BAK, COMPOSITIONS AND USES THEREOF | Sunnybrook Research Institute (CA) | 2023-08-24 | — | — | WO | disclosed |