Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 5/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23624398 | 0.90 | TNF (0.75) | TNFABCG2EGFRCLK1LCK | |
| SCHEMBL29638477 | 0.85 | TNF (0.57) | TNFABCG2EGFRCLK1LCK | |
| SCHEMBL26066602 | 0.85 | TNF (0.61) | TNFABCG2EGFRCLK1LCK | |
| SCHEMBL26066599 | 0.82 | TNF (0.64) | TNFMEN1KMT2ANPC1LMNA | |
| SCHEMBL23624526 | 0.81 | TNF (0.78) | TNFEGFRLCK | |
| SCHEMBL23624527 | 0.80 | TNF (0.52) | TNFKDM4ENPC1LMNAMAPT | |
| SCHEMBL26066566 | 0.80 | TNF (0.60) | TNFEGFRCLK1PIK3CA | |
| SCHEMBL26373508 | 0.78 | ABCG2 (0.51) | TNFABCG2EGFRCLK1LCK | |
| SCHEMBL30012590 | 0.78 | TNF (0.78) | TNFEGFRLCKMAPT | |
| SCHEMBL23611032 | 0.78 | TNF (0.78) | TNFEGFRLCKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136763-A1 | ISOQUINOLINE DERIVATIVES FOR USE IN TREATING GLUT1 DEFICIENCY SYNDROME | GLIAPHARM SA (CH) | 2021-07-08 | — | — | WO | disclosed |